HypoxEU LIVE

Basic mechanisms of oxygen homeostasis (Edurne Berra & Brian Ortmann)

• Sonia Rocha, University of Liverpool – Oxygen-dependent PHD1-mediated prolyl hydroxylation in controlling progression through mitosis
• Yoichiro Sugimoto, MDC Berlin – Beyond transcriptional regulation: direct oxygen-dependent control of molecular condensates and cellular metabolism
• Qing Zhang, UT Southwestern – Targeting oxygen sensing signaling in cancer

Flash talks:

• Adam Albanese: Phosphorylation at S345 Converts HIF-2α from a Transcription Factor to an RNA binding protein
• Maider Fagoaga: Metabolic control of oxygen sensing restrains hypoxia signaling and prostate cancer progression
• Hudson Coates: Oxygen-regulated degradation in the MYC transcriptional network

Short Break

Hypoxia in developmental and regenerative biology (Christian Stockmann & Carsten Scholz)

• Can Aztekin, Max Planck Institute, Tübingen – Hypoxia in developmental and regenerative biology
• Jess Snedeker, ETH, Zurich – The role of HIFs in tendinopathy and tendon regeneration
• Philipp Lehmann, Greifswald – Hypoxia as driver of insect development, diapause, and body size.

Flash talks:

• Yves Schild: A Human 3D PDAC-CAF Spheroid Model for Investigating HIF-2α-Mediated Immune Evasion and Vγ9Vδ2 T Cell Activity
• David Macías Gutiérrez: VEGFA Derived from O2-Sensing Cells Is Essential for Carotid Body Vascularization
• Eva Maria Ferro Abril Monteiro: Mapping the Oxygen-Responsive Proteome of UC-MSCs: Towards a Scalable Priming Strategy for Ischemic Stroke Cell Therapy

Poster Session Lunch (all posters)

Oxygen sensing as a regulator of inflammation (Peter Mirtschink and Ben Wielockx)

• Sarah Walmsley, Edinburgh, UK – Hypoxia, histone clipping and neutrophil reprogramming
• Emily DeMichele, Dublin, Ireland – Revisiting Warburg: Regulation of Tumour Cell Glucose Metabolism by Hypoxia
• Christa Maes, Leuven, Belgium – Bone Crosstalk with Energy Metabolism via Hypoxia Signaling Pathways

Flash talks:

• Katrin Stein: Impact of Elevated Ambient Temperatures on Human Dermal Microvascular Endothelial Cells Under Normoxic and Hypoxic Conditions
• Rafał Bartoszewski: The HIF Switch Revisited: Lessons from Non-Coding RNA and Post-Transcriptional Regulation of HIF Signaling
• Shweta Venkataraman: Acute systemic hypoxia alters neutrophil phenotype and function

Short Break

Metabolic Consequences of Hypoxia (Cormac Taylor & Raphael Fagundes Rosa)

• Yoshiyuki Henning, Essen, Germany – Targeting hypoxia-inducible factor-2 improves energy metabolism of the mammalian retina
• Brian Ortmann, Newcastle, UK – Chromatin modifications in hypoxiaMarco
• Marco Aurélio Ramirez Vinolo, São Paulo, Brazil – HIF-1 and the Gut Microbiome
• Edurne Berra, CIC BioGUNE, Derio, Spain – Decoding Hypoxia’s Metabolic Fingerprint Through Polyamines

Flash talks:

• Marleen Silke Oswald: The oxygen sensor FIH regulates pro-inflammatory signaling in THP-1 monocytes and macrophages
• Stephen Ariyeloye: Erythropoietin-induced gut vascular dysfunction exacerbates colitis-associated bone loss
• Eoin Cummins: Activity based sensing of CO2 using fluorescent sensors gives insight into CO2 kinetics and mitochondrial metabolism.

End Of The Day

• Hypoxia response and therapeutic indications (Peppi Karppinen (Koivunen) & Mikko Karpale)

• Betty Gardie, University of Nantes: Study of hypoxia-related genes associated with hereditary erythrocytosis
• Dörthe Katschinski, University of Göttingen: Compartment-specific hydrogen peroxide production in cardiomyocyte redox signaling and function
• Peppi Karppinen (Koivunen), University of Oulu: Cardiometabolic outcomes of roxadustat in healthy volunteers

Flash talks:

• Silvia Martín Puig: Activation of HIF signaling in microvascular cells induces non-cell-autonomous cardiac hypertrophy
• Anna-Lena Forst: Purinergic signaling under hypoxia
• Anna D. Dorsch: Pharmacologic inhibition of cellular oxygen sensors – a novel treatment option for neuroblastoma?

Short Break

Innate and adaptive immunity (Sandra Winning and Brenda Krishnacoumar)

• Kami Pekayvaz, Munich – Hypoxic monocytes acquire a HIF1a-mediated thrombus resolving profile
• Hannah Sperber, Essen – Hypoxic CD73 surface expression of HIV latently infected CD4+ T cells
• Aline Bozec, Erlangen – HIF signaling pathways affecting adaptive immune responses, inflammation, and bone homeostasis

Flash talks:

• Nelson Niski: HIF-1α Stabilization Restores Immune Metabolism in Hereditary Hemorrhagic Telangiectasia
• Sofia Ylinen: Hypoxia regulates Th17/Treg balance by altering chromatin accessibility and gene expression
• Jiyeon Ha: Hypoxia inducible factors regulate pneumovirus replication by enhancing innate immune sensing

Poster Session Lunch (all posters)

Rapid oxygen sensing and hypoxia pathway cancers (Tammie Bishop)

• Michael Jonz, Ottawa, Canada – Developmental transitions in oxygen sensing by chemoreceptors in a model vertebrate
• Tom Keeley, University of Oxford – Oxygen homeostasis – new insights into an ancient problem
• Rodrigo Toledo, CNIS – Convergent Genetic Adaptation in Populations and Tumors Under Systemic Hypoxia

Flash talks:

• Emma Jane Hodson: Stage specific effects of HIF-2 signalling in sympathoadrenal development
• Mary Slingo: The hypoxia-inducible factor prolyl hydroxylase inhibitor roxadustat increases pulmonary artery systolic pressure and enhances cardiopulmonary responses to hypoxia
• Maria Agular: NUDFA4L2 controls renal EPO producing cells hypoxic behaviour

Short Break

Keynote lecture (Introduced by Tammie Bishop)

• James Nathan, University of Cambridge – Insights into HIF dependent and independent signalling

Closing remarks by Chris Pugh

Social Hour

End Of The Day